الصحة العامة عبء الإصابة بسرطان الب

الصحة العامة عبء الإصابة بسرطان البروستاتا كبيرة. ويتوقع إجمالي 220,800 حالة جديدة من سرطان البروستاتا و 27,540 من الوفيات الناجمة عن هذا المرض في الولايات المتحدة بحلول عام 2015، مما يجعل من سرطان نونديرماتولوجيك الأكثر شيوعاً بين الذكور في الولايات المتحدة. خطر في رجل الإصابة بسرطان البروستاتا هو واحد من بين كل سبعة. سرطان البروستاتا هو السبب الرئيسي الثاني للوفاة السرطان في الرجال، تجاوزت فقط بسرطان الرئة.
تبقى أعراض بعض الرجال المصابين بسرطان البروستاتا ويموت من أسباب غير ذات صلة وليس نتيجة السرطان نفسها. قد يكون هذا بسبب سن متقدمة لكثير من الرجال في وقت التشخيص، وورم بطيء النمو، أو استجابة للعلاج. العدد المقدر للرجال المصابين بسرطان البروستاتا الكامن (أي سرطان البروستاتا التي هي موجودة في غدة البروستات ولكن ابدأ الكشف عن أو تشخيصها أثناء حياة المريض) أكبر من عدد الرجال المصابين بالمرض المكتشفة سريرياً. من الضروري فهم الآليات البيولوجية والوراثية التي تحدد لماذا بعض سرطانات البروستاتا تظل صامتة سريرياً، بينما البعض الآخر يسبب أمراض خطيرة، وحتى مهددة للحياة.
سرطان البروستاتا والمعارض الاختلافات الهائلة في حالات الإصابة بين السكان في جميع أنحاء العالم؛ نسبة البلدان مع ارتفاع وانخفاض معدلات الإصابة بسرطان البروستاتا ويتراوح المرصودة ل 100-fold. عادة ما يكون الرجال الآسيويين نسبة منخفضة جداً من سرطان البروستاتا، مع معدلات الإصابة المصححة بحسب العمر تتراوح من 2 إلى 10 حالات لكل الرجال 100,000. ولوحظت أعلى معدلات الإصابة عموما في بلدان أوروبا الشمالية. بيد أن الرجال الأمريكيين من أصل أفريقي، أعلى معدل الإصابة بسرطان البروستاتا في العالم؛ داخل الولايات المتحدة، الرجال الأمريكيين من أصل أفريقي لديهم معدل حدوث أعلى 60% من الرجال البيض. أبلغ الرجال الأمريكيين من أصل أفريقي أن يكون تقريبا ضعف معدل الوفاة – خاصة بسرطان البروستاتا مقارنة مع الرجال البيض من أصل غير إسباني. يجوز تضييق الفروق في تقديرات البقاء على قيد الحياة سرطان البروستاتا الخاصة بسباق مع مرور الوقت.
قد تكون هذه الاختلافات نتيجة للتفاعل بين التأثيرات الوراثية والبيئية والاجتماعية (مثل إمكانية الحصول على الرعاية الصحية)، التي قد تؤثر على التنمية وتطور المرض. الاختلافات في فحص الممارسات أيضا كان له تأثير كبير على الإصابة بسرطان البروستاتا، بالسماح بسرطان البروستاتا تشخيص بعض المرضى قبل وضع الأعراض أو قبل شذوذ في الفحص البدني قابلة للاكتشاف. واقترح إجراء تحليل للبيانات المستندة إلى السكان من السويد أن تشخيص الإصابة بسرطان البروستاتا في أخ واحد يؤدي إلى تشخيص مبكر في أخ ثاني باستخدام فحص مستضد البروستات محددة (PSA). وهذا قد تمثل زيادة في سرطان البروستاتا في الرجال الأصغر سنا تشخيص كان واضحا في بيانات الإصابة على الصعيد الوطني. مساهمة وراثية إلى خطر الإصابة بسرطان البروستاتا وقد تم توثيق، وهو زيادة المعرفة بعلم الوراثة الجزيئي للمرض، وعلى الرغم من أن الكثير من ما هو معروف لا سريرياً للتنفيذ بعد. تحول الخلايا الظهارية البروستاتا الخبيثة وتطور سرطان البروستاتا من المحتمل أن تنجم عن سلسلة معقدة من استهلال والأحداث الترويجية تحت التأثيرات الوراثية والبيئية على السواء.

النتائج (الإنجليزية) 1:

Public health burden of prostate cancer is great. A total of 220,800 expects new cases of prostate cancer and 27540 deaths from this disease in the United States by 2015, making it the most common nondermatologik cancer among males in the United States. Danger man prostate cancer is one of the seven. Prostate cancer is the second leading cause of cancer death in men, exceeded only by lung cancer.Keep the symptoms of some men with prostate cancer and died of unrelated causes rather than the cancer itself. This may be due to the advanced age of many of the men at the time of diagnosis, and slow tumor growth, or response to therapy. Estimated number of men with prostate cancer latent (i.e. prostate cancer that is found in the prostate gland but never detected or diagnosed during the life of the patient) is greater than the number of men with the disease detected clinically. It is necessary to understand the biological mechanisms and genetic determined why some prostate cancers remain clinically silent, while others cause serious illness, and even life-threatening.Prostate cancer and exhibits tremendous differences in incidence among populations worldwide; the proportion of countries with high and low incidence of prostate cancer and the allocated ranges of 100-fold. Asian men usually have very low rate of prostate cancer, with incidence rates age-adjusted ranging from 2 to 10 cases per 100,000 men. The highest incidence was observed generally in Northern European countries. However, American men of African descent, the highest incidence of prostate cancer in the world; in the United States, African American men have the highest rate of 60% of white men. The men told African-Americans have almost twice the death rate — especially prostate cancer compared with white men than non-Hispanic origin. May be narrowing differences in estimates of survival of prostate cancer for a race with time.These differences may be due to the interaction between genetic and environmental influences (such as access to health care), that may affect the development and progression of the disease. Differences in screening practices also had a significant impact on the incidence of prostate cancer, prostate cancer diagnosis, some patients develop symptoms or by abnormalities on physical examination, discoverable. He suggested that an analysis of population-based data from Sweden to diagnose prostate cancer in one brother leads to early diagnosis in another second using check prostate-specific antigen (PSA). This may represent an increase in prostate cancer in younger men diagnosed was evident in the incidence data at the national level. The genetic contribution to risk of prostate cancer has been documented, is to increase the knowledge of the molecular genetics of disease, and although much of what is known clinically not for implementation. Malignant transformation of epithelial cells of the prostate and prostate cancer develops is likely to result from a complex series of launch and promotional events under genetic and environmental influences.

النتائج (الإنجليزية) 2:

Public health burden of large prostate cancer. And it is expected to total 220 800 new cases of prostate cancer and 27 540 deaths from this disease in the United States by 2015, making it the most common among males in the United States Nondermatulogik cancer. A man in danger of prostate cancer is one out of every seven. Prostate cancer is the second leading cause of cancer death in men, exceeded only lung cancer.
Remaining symptoms of some men with prostate cancer die from causes unrelated and not as a result of the cancer itself. This may be due to the advanced age of many of the men at the time of diagnosis, and slow tumor growth, or response to treatment. Estimated number of men with prostate cancer underlying (ie prostate which is present in the prostate gland cancer but never detected or diagnosed during the patient's life) is greater than the number of men who have the disease detected clinically. It is necessary to understand the biological and genetic mechanisms that determine why some prostate cancers remain clinically silent, while others cause serious diseases and even life-threatening.
Prostate cancer and exhibits enormous differences in the incidence among the population in all parts of the world; the proportion of countries with high and low cancer rates Prostate ranges observed for 100-fold. Asians usually have a very low ratio of men from prostate cancer, with incidence rates adjusted by age, ranging from 2 to 10 cases per 100,000 men. It observed the highest rates generally in northern European countries. However, American men of African descent, the highest incidence of prostate cancer in the world; in the United States, American men of African descent have a higher rate of 60% of white men occurs. American men of African descent reported to be almost double the death rate - especially prostate cancer compared with white men of non-Hispanics. May narrow the differences in survival for prostate cancer race with time estimates.
This may be differences as a result of the interaction between genetic and environmental and social impacts (such as access to health care), which may affect the development and progression of the disease. Differences in screening practices also had a significant effect on the incidence of prostate cancer, prostate cancer diagnosis by allowing some patients before symptoms develop or before abnormalities on physical examination are discovered. It was suggested that an analysis based on data from Sweden to the population that the diagnosis of prostate cancer in one brother lead to early diagnosis in the second brother screening using prostate-specific antigen (PSA). This may represent an increase in prostate cancer in younger men diagnosed it was not clear in the incidence of data at the national level. Genetic contribution to the risk of prostate cancer has been documented, which is to increase knowledge with the knowledge of the molecular genetics of the disease, and despite the fact that a lot of what is known is not clinically after implementation. Transformation of prostate epithelial malignant cells and the development of prostate cancer are likely to result from a complex series of initiation and promotional events under genetic and environmental influences on both.

النتائج (الإنجليزية) 3:

"The public health burden of prostate cancer. The total of 220,800 new cases of prostate cancer, 27,540 deaths from the disease in the United States by 2015, making it the most common Nwndyrmatwlwjyk cancer among men in the United States. A man of prostate cancer risk is one in seven.Prostate cancer is the second leading cause of death of cancer in men, only lung cancer surpassed.
remain asymptomatic men with prostate cancer die from causes other than related and not due to cancer.This may be due to advanced age, many men at the time of diagnosis, slow tumor growth, and response to treatment.The estimated number of men with prostate cancer morbidity (i.e., prostate cancer, which is present in the prostate gland but never disclose or diagnosed during the lifetime of the patient. The number of men with MS diagnosed clinically.It is necessary to understand the biological and genetic mechanisms that determine why some prostate cancers remain clinically silent, while others cause serious disease, and even life-threatening. "Prostate cancer and exhibits considerable variations in incidence among populations all over the world; the proportion of countries with high and low incidence of prostate cancer is provided to 100-fold.Usually Asian men only a very low proportion of prostate cancer, with age standardized prevalence rates ranging from 2 to 10 cases per 100,000 men. The highest incidence rates generally in the Nordic countries.